Environmental Influences Essay

A global plastic manufacturer, Riordan Manufacturing is on top among others in the field of plastic injection molding, with annual projected earnings of $46 millions. As an industry leader, Riordan have a labor force of 550 employees and have state-of-the art design capabilities that create innovative plastic designs which won an international acclaim. With its present capabilities, Riordan remains a strong and vibrant company in the industry. Riordan’s plan to open up new business in other country is not new as Riordan manufacturing has one in China. India is another country that has a strong potential for business to thrive. However, the company needs to consider pertinent ethics issues that are highly valued in that country. Of Course, India is a country with very sensitive culture especially in matter of religion. Which you identify the three most pertinent ethics issues faced by Riordan Manufacturing in conducting business in your selected country The most pertinent ethics issues Riordan manufacturing must take into considerations in putting up business in India should be the following; discrimination, sensitivity to local customs and tradition, and sensitivity to the economic condition of the society. While Riordan’s primary interest is to gain profits, they certainly need a strong workforce to facilitate its operation. However, Riordan manufacturing must address the ethics issues of discrimination confronting the employee-employer relationship in relation to employment. The ethics issues involve in hiring employees lies on how the management treats their employees, which according to Crane and Matten (2007) can serve as a moral hazard to employees. The situation of the Indian economy is potential breeding ground for discrimination as the government allows the hiring of employees on contractual basis. Davenport, Crotty, and Torres cited that Indian Law â€Å"starts from the common law premise that an employer has a right to terminate the services of an employee without giving a reason. Riordan Manufacturing can easily fall into temptation to exploit this law to serve its own interest at the expense of the contractual employees. Although it might be allowed by law, terminating employees merely on the ground of fixed contact terms allows the company to select the kind of employees they desired. This is discrimination because in effect, they are ejecting employees they do not like in favor of others whom they desired. Crane and Matten stated that discrimination in essence â€Å"is a violation of Rawl’s Theory of Justice, that social and economic inequalities are to be arranged so that they are attached to the offices and positions open to all under conditions of fair equality of opportunity† (p. 273). The next ethics issues faced by Riordan Manufacturing in conducting business in India are the sensitivity to local customs and tradition. India is known for its religious culture of regarding life as sacred whether human or animal life. Indeed, for Hindus, cows are sacred. Failure to respect local customs and tradition proved to be disastrous. This is clearly seen in the case of Disneyland in Paris whose initial failure was blamed for Disney’s lack of sufficient awareness of the local cultures. Riordan Manufacturing therefore must be aware of India’s local customs and traditions in order not to repeat the same mistake that caused Disney Company hundreds of millions of dollars in losses during the initial years of Disneyland in Paris. Since the company’s products are plastic beverage containers, it assumes no direct connection to what the Hindus regarded as sacred, however, Riordan manufacturing must be able to draw a clear concept reflecting the company’s fair dealing and high regard for ethical issues. Finally, Riordan Manufacturing must be able to demonstrate sensitivity to economic condition of the community. The company must contribute to the local government’s effort of community development by first of all providing employment opportunities to local residents, paying required taxes and other required fees to the local government, and avoid any express transactions via under the table arrangements. Riordan Marketing should also able to recognize its role not only as profit oriented company, but also a business organization responsible to both its shareholders stakeholders. That is, the company must care for the environmental and cultural impact of its business operation. How do these ethics issues impact Riordan Manufacturing’s marketing efforts Negatively, the lesson that was learned by Disney Company during the initial years of its operation in Paris is the answer how these ethics issues can impact Riordan manufacturing’s marketing efforts. Failure to consider these ethics issues will certainly lead to serious losses as it will affect the domestic market’s behavior in view of indifferent patronage of Riordan’s product. As Chryssides and Kaler (1993) pointed out, Riordan Marketing must recognize that business â€Å"is not just a matter of economic exchange of money, commodities, and profits; it involves human interactions, is basic to human society, and is intertwined with the political, social, legal, and cultural life of society (p. 37). Riordan Marketing’s failure to settle the ethics issues as cited above could seriously damage the marketing of the product and might even come to worse if a campaign to boycott the product will be spearheaded by any radical organization. India, being second most populous nation on earth and is a fast industrializing economy can be a huge market for Riordan Marketing promising a potential profits for the company. Positively however, the ethics issues discussed above can provide Riordan a positive image and insure domestic patronage if those ethics issues are observed by the company. The ethics issues properly addressed can reduce the negative impact of marketing, and it will also enhance the consumer well-being. Vilcox and Mohan (2007) aptly stated that ethics issues can â€Å"increase its positive impact by providing consumers with goods and services that can enhance their overall quality of life† (p. 50). The impact therefore of those ethics issues can be achieved by the company through creating a positive company image based on cultural awareness, respect and incorporating the customs and tradition to the company’s business strategy. If Riordan Manufacturing also wanted to consider marketing to a broader region that included your selected country (e. g. , Europe, Asia), what impact would this have on their marketing strategy? The impact Riordan Manufacturing’s marketing to a broader region is dependent of the company’s overall image. Based on the company’s history and current business performances, Riordan Manufacturing enjoys a very highly organized and well secure business transaction. They have no bad previous records in terms of their internal operation. The company’s human resource has an excellent policy with regard to employee-employer relationships and in terms of benefits the company provides its employees. The company’s ethical reputation of the company will certainly have good impact on their regional marketing strategy. Indeed, Riordan Manufacturing’s marketing strategy is ethical marketing. In a paper entitled â€Å"PR Campaign: Final Paper† of the University of Phoenix Public Relation dated 2007, the paper stated that Riordan Manufacturing is focused on creating an organization that recognize the individual employee’s importance to the company. According to the paper, the Riordan Manufacturing is bent on creating a socially responsible company to the community which is the stakeholder in this case. Furthermore, the company is doing its best to inform the public that although their products may not always be environmentally friendly, they are completely conscious of the public concerns (PR Campaign). Thus, even if Riordan Marketing will consider marketing to a broader region that includes India, it will not have negative impact on their marketing strategy especially in India because they have not violated any cultural issues or the local customs and tradition of the host country. Rather, addressing ethics issues such as those discussed above will always yield potential gains for the company. Considering that Riordan Manufacturing’s marketing strategy is it self ethical marketing, it means they are on the right track as ethics deals with what is good for the majority. The impact of these ethics issues is that it will enhance the company’s public relations that will surely have an immense impact on Riordan Manufacturing’s marketing strategy. The point therefore is clear, Riordan Manufacturing’s success in creating a company that is highly anchored on ethical principles and values will help them determine its course of success both in the broader region and in a particular country like India. In the meantime, Riordan Manufacturing is on its way of transforming itself towards a company that cares on every spheres of their operation ethically. They are a company that acknowledges responsibility on all their stakeholders beginning from their own employees, the organization, the community, and the country where it operates. Reference List Crane, A. & Matten, D. (2007) Business Ethics USA: University Press Chryssides, G. D. & Kaler, J. H. (1993) An Introduction to Business Ethics UK: Cengage Learning EMEA Davenport, G. , Crotty, M. , Torres, P. (2000) Termination of Employment Digest Switzerland: I LO Pr Campaign: Final Paper January 29, 2007 http://www. oppapers. com/essays/Pr-Campaign-Final-Paper/119681 Vilcox, M. W. & Mohan, T. (2007) Contemporary Issues in Business Ethics New York: Nova Science Publishers, Inc.

Dracula Transformation Essay

Shadow of the Vampire is a post-modern text which is a reconstruction of Dracula, a novel by Bram Stoker, and Nosferatu a film directed by F. W. Murnau. The use of intertexuality in Shadow of the Vampire is a key aspect which allows it to echo; themes, the gothic mode and issues that are present in the other two texts. Through a clear pastiche, Merhige produces a new text from the old. Immortality is a key theme which has been subverted from the physical sense through sucking blood, as it’s represented in Dracula, to the spiritual sense through art by producing a perfect film which will outlast and entertain many generations. Bram Stoker uses many motifs such as the; wafer, stake, crucifix and garlic flowers to demonstrate the Count’s immortality as these reoccurring symbols show the limited objects that can rid of a vampire, emphasizing his strength and power. Although these symbols are all present and continual in Shadow (‘crosses aren’t for decoration’- villager says to Murnau), they don’t portray the immortality, instead Merhige uses film techniques to replace the language techniques of Dracula. The zoom in of the camera is an example as it shows the deep expression and desperation of Murnau to achieve his perfect picture and effectively his immortality. Dialogue and particular quotes make his goal obvious; ‘our memory won’t blur or fade’ and ‘context that will last like the graves’ and also shows his obsession to earn immortality. Murnau’s obsession with his picture in Shadow causes him to turn into the mad protagonist of the film and instead all our sorrowful emotions become aimed at Count Orlock, who is a poor and weak replication of the vampiristic image set by Dracula1. In Dracula the protagonist (being the Count) also becomes obsessed with immortality and the female characters (Mina and Lucy) as he repeatedly visits them; the illicit love that Dracula has for these women adds to the terror and gothic romance of the novel. As the female characters become threatened and distressed by the Count, they add to the suspenseful and mysterious atmosphere and engage the reader as they share similar emotions; 2 the female character of Greta in Shadow is a resonance of this distress as she is unknowingly affected by the presence of Orlock which causes her to turn to drug abuse to deal with it (does too Murnau and the producer). Greta is also unknowingly being distressed by the camera itself which acts as a symbol for an oppressive male protagonist which contains characteristics of Dracula: her naive comment; ‘theatre gives me life, this thing only takes it away’, is an example of irony and also foreshadows future events and feelings; such as she subconsciously knows it (like her other comments) but instead of acting upon it she again turns to drugs to avoid the fact. Murnau’s obsession is proven by his willingness to use other people as sacrifices, most notably Greta as he makes a deal with Orlock for her life. The flashbacks of Greta (before she is fed upon) causes shock to the viewer as the quotes like; ‘consider it a sacrifice for your art’ and ‘make the ultimate sacrifice for love’ cause the emotions of: sorrow, horror and excitement to flourish as the viewer realises Murnau’s ambition from the start and its inevitability. These quotes are well-crafted examples of foreshadowing and irony. His obsession with his art is continuously shown throughout as he makes ridiculous demands and is easily aggravated, such as when the photographer was bitten by Orlock, Murnau exclaimed; ’’lack of enthusiasm, I told you to fix it’’. In Dracula sacrifice is dominantly practiced in a positive way with the heroic group making many sacrifices to finally reach their goal of destroying Dracula; (however, this heroic group is omitted in Shadow and is the primary reason for Murnau’s success). Arthur sacrifices his love for Lucy to save her soul and his own, but as a result he must kill her gruesomely; also, the men (Morris, Billington, Van Helsing and Seward) sacrifice their blood in transfusions to keep Lucy alive. This is foreshadowed by Lucy as she previously exclaimed ‘if only I could have them all’ when she was deciding her lover between these men; this gives the blood sexuality to it (sexual innuendo) and this is an example of gothic romance with the presence of rival lover and multiple suitors. This sexuality of the blood is present in quotes such as: ‘the girl went on her knees†¦Ã¢â‚¬â„¢ and ‘away with you, he’s mine’ and these show the ruling and empowerment of the male characters in a patriarchal society. The sexuality given to blood in Dracula is again subtly echoed into Shadow of the Vampire, with Orlock’s lust and desperation for Greta being portrayed in the sexual sense as he is given blood from bats and other sources throughout the film but none satisfied him like Greta with him falling asleep soon after to lighten the mood with black humour before the action-packed ending is aroused. The mysterious atmosphere that is obvious in all three texts is similarly brought about through the usage of slightly subverted gothic elements and techniques. The empty and ruined castle setting of Dracula is important to setting the original supernatural/gothic tone that the novel continues throughout: as shown by Jonathan Harker’s diary entries; ‘the castle is a veritable prison and I am a prisoner! and ‘doors everywhere, locked and bolted’. Additionally, the position of the castle adds to the mystery; ‘just on the borders of three states†¦ portions of Europe’ as these names aren’t familiar to us. Shadow of the Vampire incorporates this setting as; small rooms, caves and an abandoned monastery are all used in the majority of the film and the transition of filming from the developed west to the unknown and strange east (Helgoland). Both texts also use the dark of night to represent the dark, supernatural tone that each are setting: Stoker uses the sun as a symbol of protection from evil (the dark) and is evident in comments of Mina; ‘I keep waiting till the sun†¦ be to me a safety’ and ‘that beautiful sun†¦ life was to me again’. Shadow of the Vampire sets most of its scenes in the dark and uses images of the silhouetted moon and shadows together with eerie background music to make the viewer feel uncomfortable and scared like the characters. Shadow uses haunting sounds like thunder and howling in night scenes to give the supernatural sense (in the same way Nosferatu does); which is an echo of the onomatopoeia used by Stoker such as; ‘muffled roar’ and ‘howling of dogs’. Both texts also make use of the gothic palette as a dominator of the colours used because they give the sense of age (grey), danger (red) or evil (black) which are essential to the quick-shifting moods as they hint to the audience what’s coming up next. Overall, the incorporation of a post-modern style and the subversion and inclusion of themes, issues and gothic elements from Nosferatu and Dracula were crucial to the success and transformation of Shadow of the Vampire. The continual success of this film is due to its excellent depiction of vampires and their nature which can be evident in modern day life and in the character of people; which has never been paralleled as it’s so ‘ferociously original’.

A Proposal to Purchase Echocardiography Machine

Dear Sir, I would like to offer the proposal of purchasing an echocardiography machine, which in my suggestion is an urgent need for our hospital because of its large cardiac department.I would like to put forward my proposal in front of the panel of judges to justify my urge to buy the equipment as it is a need and an asset to the hospital as well.Such costly equipment should only be purchased when trained staff, ready to give undertaking of its optimum utilization, is available. This becomes all the more important when the financial constraints in the institution are so severe that even life saving medicines and common use items are not available even in the Emergency.EchocardiographyEchocardiography is a technique that uses very high frequency sound, or ultrasound (with frequency between 2 and 15 MHz, well above the human hearing limit of about 20 kHz), to visualize the details of heart anatomy. Echocardiography is the most widely used diagnostic test to detect and quantify heart disease. It has been used in virtually all areas of cardiovascular examination, evaluation and management.There is growing interest in the smaller, portable, hand-carried devices because they offer the ability to bring echocardiography to point-of-care management, particularly for cases that previously required delays in testing due to the necessity of scheduling sonographers and moving equipment through the hospital.Hand-carried devices have the potential to be used in areas such as the critical care unit (CCU), the cardiac catheterization laboratory, the electrophysiology laboratory, the emergency department and all surgical intensive care units.There is also a rising conviction that because of the ease of use of the hand-carried ultrasound, it eventually will be incorporated into the standard physical examination, much like the stethoscope is today.Price Of Echocardiography MachineAn echocardiography machine can be purchased at approx $125,000 (Leech, 1998). These machines do not depreciate easily physically; however, they rapidly become outdated technically. An echocardiography machine practically and technologically can not live up to five years. For this reason, and to give a better life to the machinery, the manufactures regularly provide upgrades to the machines, which enhance the technical life of the machine to up to 12 years.To take a rough idea, the up-gradation at the rate of at least 5 % per year of the purchasing cost, will cost $30,000 to every 3–5 years. As capital sum can generate some bank interest could, the ‘cost of money’ is required to be included. In the United States, the Government’s Treasury rate is 6%. Servicing the machine will be charged annually at approximately 6–8% of the purchasing cost (Leech, 1998).

Students should not do H.W after school day Assignment

Students should not do H.W after school day - Assignment Example It does not allow the students to engage in other sectors of life thus they feel the topic has come to their rescue. The audience belief that teachers should at least make sure that students understand their homework before they give it to them. They also believe that students should use not more than thirty minutes undertaking their homework and that homework should not be allocated in the weekends. This is the time the students should conduct their own activities outside school. To convince the audience, I would use the causal reasoning. This would be reasoning where I identify the relationship that exist between a cause and the effects. I would explore the causes of giving out homework and the effects of giving out homework. From there, I would reach into a conclusion with them. I would elicit a hopeful emotion to my audience. This would be through driving my motion home and convince our school not to dish out homework to the students. They should allocate some time in school for students to complete their

Role of MIS department Essay Example | Topics and Well Written Essays - 500 words

Role of MIS department - Essay Example The identification of issues that may lead to poor technology management may be the first step in making this improvement possible. Talking to the employees in the department about the use of technology management can improve the attitude they have about the system. Attitude among the staff may be one of the reasons that enable people to do as they wish. Finding out what it is that encourages them to work better with such a system is crucial in improving the system (Megantz, 2002). Privacy issues are also the main cause of poor technology management. Personal information being the key component in running the technology system, employees may be reluctant to give out this information. This is because of fear that people may steal their identities. An example is the login requirement that is present in every system, in a company. This may be the reason as to why it is difficult for them to use the technology system to attain their goals (Megantz, 2002). There might be some strategies that may be used to improve technology management. One of these strategies would be to state the goal of the system. Stating it to the employees in the department is a strategy that enables them to create a target for themselves (Dorf, 1999). In this scenario, every department it is responsible for a set target by the company, and that it must be realised. Another manner in which technology management can be improved is through the creation of a modest learning cycle. This learning cycle helps improve the manner in which employees decide to use the technology system. If they are set in a manner that will deal with the issues that arise from the use of such methods, then it is possible the system can be improved (Dorf, 1999). This may lead to an improvement in the company’s dealings. Using a timeframe strategy for producing results is usually the

Personal Statement (one page essay on reasons for choosing medicine)

Personal Statement (one page on reasons for choosing medicine) - Essay Example Perhaps because of my early fascination with frequent traveling with my parents, I have never really put a big effort into my BSc. (I am about 90 credits in.) Saving other people’s lives is something that I would like to do. I feel like I have taken enough from this world and now its time to put a little back in it. There is a pride, I think, in being a doctor, but there is also the challenge to make good. Imagine the beat of life lying in your hands but you would have to think and move to be an instrument to let that beat continue on and live. Imagine that those lives are the very ones to also let other lives beat on. If I were that doctor, how great is the challenge to answer the hopes of families gaping at you for answers. This is the kind of life I would like to go into. There is meaning and there is purpose. All the time my life was suspended on air, I would think of these things. Life are precious it could crumble anytime. But it could also be saved. If given the chance, I would like to join the medical world. At least, I could say I am useful for others after all. I am a voracious reader of all types of books. As such, it will not be strange to me to be meeting requirements in school for much reading and research. I am proficient in English besides. Aside from my concern for mental health, I also go for physical health. I exercise regularly and enjoy all sorts of sports but mainly skiing. Ive been told that Im very personable and easy to get along with. Therefore, if I would be mixing with other cultures in school, I am ready for it. Over in my church community, I meet all sorts of people. I think I am of the gregarious kind and this is no problem. When one becomes a doctor, he doesn’t look into the color of the patient’s skin before he decides to serve. I volunteer at a Union Gospel Mission soup kitchen whenever I get to church as this is my way of mixing with the community. I love the feeling that I can be of use

Professional Values, Ethics and Law Essay Example | Topics and Well Written Essays - 2250 words

Professional Values, Ethics and Law - Essay Example Values comprise of a set of socially accepted codes of conduct and in medical profession, values are the standards of conduct or professional responsibilities that are informally accepted and passed on as traditions (Beauchamp & Childress, 2001). Alongside advances in the science of medicine, attempts have been made by moral theorists to codify the ethical and moral principles involved. These principles provide guiding framework that help avoid dilemmas in conflicting situations. The two pioneer ethical theories include Teleologic theory or Consequentialism/Utilitarianism and Deontologic or formalist theory. The Utilitarianism theory focuses on the end and judges actions on the basis of greatest good for a larger group of individuals. Deontological ethics introduced by John Stuart Mill, and supported by Immanuel Kant was judged actions on the basis of motive underlying it. Irrespective of the results or individual opinion, duty must be accomplished without any choice. Principles and duty guide actions. In this respect American Nurses Association (ANA) Code of ethics for nurses provides that the nurses’ primary commitment is to the patient, his health, rights and safety. Further the nurse is solely responsible for his practice. The ethical principles guiding nurses enable them to take moral positions in specific situations (Ivanov & Blue, 2008). Beauchamp & Childress have grouped these principles into four categories: respect for autonomy

ART Essay Example | Topics and Well Written Essays - 1500 words

ART - Essay Example The cemented room has white tiles on one wall and the smaller animal is seemingly coming from another room. The two animals are white in color. Michael Amick divided the photo into three parts, which include the foreground and the background. The picture depicts a cool environment since the two animals are all alone in the room. In the foreground of this picture, I can see the bigger animal jumping towards the red wall. I can also see its image beneath it. The animal is seemingly closing its eyes and has four legs. I can also see the three red walls and the white-tiled wall on the foreground. The white color of the tiles and the animal suggests peace and hence the cool environment. The red wall signifies danger but there is no conflict in the room and hence peace supersedes danger in this picture. The two colors add beauty to the picture and the animal is seemingly made of limestone. I can see the smaller animal in the background as well as its image. I can also establish that the four walls are seemingly converging at the background. The small animal is also white in color and only its front legs are visible as it is seemingly coming from another room. The white knob on the foreground of the white wall and the position of the shadows suggest that the white side depicts the roof of the room. Indeed, the animals are few meters from the roof and jumping from one room to another. The position of the shadows of the two animals suggests that the source of light in this picture is at few meters above the animals. Probably, the source of light is an electricity bulb on the roof of this room. The author uses a red color, which is bright, and a white color, which is calm. As such, the picture suggests a bright and calm life as depicted by the environment. The picture manifests lack of conflict and the presence as the animals jump freely from one room to another. The colors in the picture create a comfortable contrast, which is attractive

Class Dialogue Assignment Example | Topics and Well Written Essays - 250 words - 4

Class Dialogue - Assignment Example Moreover, the book provides insights on how there have been faithful communities who have passionately followed the way of Christ despite the numerous challenges they face. b.) Pope Francis’ Evangelii Gaudium Chapter II # 50-60; Chapter IV # 186; # 198 Accessed Online from http://w2.vatican.va/content/francesco/en/apost_exhortations/documents/papa-francesco_esortazione-ap_20131124_evangelii-gaudium.html The source provides diverse issues and themes that relate to how human beings relate to one another and to the environment. Chapters II (50-60) elaborates on the challenges that humanity is facing in the modern world that range from idolatry of money, having financial systems that rules rather than serving, inequality that leads to violence to cultural challenges. Chapter IV (186-198)emphasizes on the inclusion of the poor in the society, communities and individuals as instruments of God to liberate and promote the poor, man’s union with God, the fidelity to the gospel and the special place of the poor in God’s people. In addition, the chapter discuses solidarity as a spontaneous reaction by people who recognize that the societal function of property and the general destination of goods are certainties that come before private material goods. It is a relevant source to the topic at hand because it provides information about the current issues (both social and religious ) that are taking place in the modern world. Bishop Kenneth urges people not to forget the poor and the needy and that we should always give them a priority in whatever we are doing. He urges people not to ignore them because of their status and also to help them indiscreetly. Moreover, Bishop Kenneth challenges people that everyone is capable of helping the needy (poor) irrespective of how little they have since what matters most is giving with a willing heart. This quote argues that the modern world has changed to be full of inequalities whereby it is only the strongest who can survive

The Role of Early Relationships Essay Example for Free

The Role of Early Relationships Essay In this assignment I will discuss the role of early relationships in the development of child behaviour. This involves many factors such as the family, child rearing styles, theory and development of attachment. I will discuss and explain experiences which I have come across within the childrens sector and how these are influenced by the developmental theory. I will then discuss in depth how the main developmental perspectives play a part in early years. P3. The role of family when considering child rearing is vital as this is where the bonding process begins; as this bond is formed the child develops an attachment to the person therefore creating a relationship. This bond in the beginning is primarily developed with the babys main care provider, not necessarily the mother, as children are brought up in diverse family structures. Family structures such as: nuclear family which involves both parents being together to bring up the child not relying on others for support, lone parent families which is either the mother or father bringing the child up with out the support of a partner, reconstituted families where two adults become partners whilst parenting children from a previous relationship and finally extended families where there is a close knit support from other family members such as grandparents who live together with the parent(s) and child. Many families dont fit ideally into just one of these support units and may be a single parent family with the close support of other family members even though they do not live together as one family unit, this then affects the people which the child develops primary attachments with as the parent may work and the grandparents become the main childcare providers for the child therefore forming multiple attachments. P3. The ways in which child rearing has developed over time has changed dramatically not only due to the ways in which a family is structured but how the care is managed. The first theory of child rearing was developed by Truby King he suggested babies should be toilet trained as young as possible, have a feeding routine and spend lots of time outdoors in order to reduce the chances of infant mortality and disease therefore cutting down the adult to child contact. We now realise that this would affect the childs opportunities to bond, develop relationships and attachment with its carers. During the 1950s and 1960s Benjamin Spock, whos theory is more child-lead than the previous, emphasised the importance of building a strong relationship between the child and its carers by encouraging parents to be more flexible with the child illustrating more affection listening to the childs individual needs but still appreciated the need for a routine. His suggestions, which were published as a guide to parents, counteracted the strict advice of paediatricians and doctors at this time. Medical professionals insisted that unremitting feeding routines should be undertaken whilst they also disapproved of parents openly showing affection towards their child. What good mothers and fathers instinctively feel like doing for their babies is usually best after all (Spock B, Saidwhat.co.uk) His theory was focused on the physical aspect of relationship development believing that the child should be wrapped up to give them the feeling of security as they had in the womb of their mother, he believed that routine changes and feeds every four hours would suffice the child and leave them feeling happy, he also believed that a babys every cry should not be answered if the routine was in place as they didnt physically need anything more. P3. Penelope Leach developed further this approach suggesting that child rearing should be child-centred rather than child lead, meaning that responding to the childs social, emotional and cognitive needs not only reaffirmed the child but also the parents by allowing more bonding time. She helped parents understand their childs needs and cries, suggesting on-demand feeding is a better approach than feeding at set times as it better suits the childs individual needs. Leach therefore allowed parents to be carers of their child permitting them to spoil their child with love and affection rather than being there to enforce control and discipline. P3. Kitzinger looked into this further in the mid 1970s and believes that a child should be cared for in a way that is natural and instinctive for both the child and the mother. Sheila Kitzinger says that parents need to see their children as social beings that need human interaction and companionship not just servicing by being fed, bathed and changed.

The Worst Natural Disasters In History History Essay

The Worst Natural Disasters In History History Essay The Black Death had many long-term consequences. One was a series of vicious attacks on Jews, lepers, and outsiders who were accused of deliberately poisoning the water or the air. Lepers were singled out and persecuted. Anyone with a skin disease such as acne was thought to be a leper. They were, for the most part, exterminated throughout Europe. The attacks against Jews began in the south of France, but were most dramatic in parts of Switzerland and German areas with a long history of attacks on local Jewish communities. Jews were rounded up and burned or drowned in marshes. Sometimes there were attacks on Jews even where there was no plague. This persecution was often done, not solely out of religious hatred, but as a way of attacking the Kings or the Church who normally protected the Jews. Jews were often called the Kings property and it was a way for people to lash out at the institutions who they believe had failed them. Fewer Jews died from the Black Death, in part due to rabb inical law which called for a lifestyle that was, in general, cleaner than that of a medieval villager. It is estimated that between one-third and one-half of the European population died from the outbreak between 1348 and 1350. As many as 25% of all villages were depopulated, mostly the smaller communities, as the few survivors fled to larger towns and cities. The Black Death hit the towns and cities disproportionately hard. Some rural areas, for example, Eastern Poland and Lithuania, had such low populations and were so isolated that the plague made little progress. Larger cities were the worst off, as population densities and close living quarters made disease transmission easier. Cities were also infested with lice, fleas and rats, and subject to diseases related to malnutrition and poor hygiene. The influx of new citizens facilitated the movement of the plague between communities, and contributed to the longevity of the plague within larger communities. Bremen in Germany lost almost 7,000 of its 12,000 inhabitants. The prosperous city of Florence, Italy, may have lost 40,000 of it s nearly 90,000 inhabitants. Nearby Siena probably lost two-thirds of its urban population. Paris, the largest city north of the Alps, lost more than 50,000 of its 180,000 inhabitants. Most major cities were quickly forced to create mass graveyards where the dead could be buried. Many towns and villages lost almost all of their populations, and some eventually disappeared altogether. Larger towns declined drastically, as their workforces and merchant classes either died or fled. European population only began to grow again in the last decades of the 15th century. The precise demographic impact of the disease in the Middle East is impossible to calculate. Mortality was particularly high in rural areas. Many surviving rural people fled, leaving their fields and crops, and entire rural provinces are recorded as being totally depopulated. Surviving records in some cities reveal a devastating number of deaths. The 1348 outbreak in Gaza left an estimated 10,000 people dead, while Aleppo recorded a death rate of 500 a day during the same year. In Damascus, at the diseases peak in September and October 1348, a thousand deaths were recorded every day, with overall mortality estimated at between 25 and 38 percent. Syria lost a total of 400,000 people by the time the epidemic subsided in March 1349. In contrast to some higher mortality estimates in Asia and Europe, scholars believe the mortality rate in the Middle East was less than one-third of the total population, with higher rates in selected areas. The plague did more than just devastate the mediev al population. It caused a substantial change in the economy and society in all areas of the world. Economic historians have concluded that the Black Death began during a recession in the European economy that had been under way since the beginning of the century, and only served to worsen it. Europe had been overpopulated before the plague, and a reduction of thirty percent to fifty percent of the population should have meant less competition for resources. There was more available land and food, and higher wages. The great population loss brought economic changes based on increased social mobility, as depopulation further eroded the peasants already weakened obligations to remain on the land. In Western Europe, the sudden scarcity of cheap labor provided an incentive for landlords to compete for peasants with wages and freedoms, an innovation that, some argue, represents the roots of capitalism. The resulting social upheaval caused the Renaissance and even Reformation. In many ways the Black Death improved the situation of surviving peasants. In Western Europe, because of the shortage of labor, they were in more demand and had more power. Because of the reduced population, there was more fertile land available. However, the benefits would not be fully realized until 1470, nearly 120 years later, when overall population levels finally began to rise again. The death of so many people concentrated wealth in the hands of survivors. In many cases, those workers who remained alive could earn up to five times what they had earned before the plague. In the towns, plague had the effect of consolidating wealth somewhat, especially among the middle class. The drop in population was accompanied by a corresponding rise in per capita wealth. There where large increases in spending in the towns at this time. Profits, however, for property owners and merchants declined as they found themselves having to pay higher wages and getting less when they sold their products. Property owners tried to collect higher fees from tenant farmers as a way to increase declining incomes. Higher payments to landowners and legal limitations on the rights of some peasants were implied. Economic and political unrest occurred in most parts of Europe during the second half of the 14th century. The Black Death changed religion drastically. The old religious moorings were weakened. Many believed the wrath of God seemed to be raining upon earth. Symptoms of mass neurosis appeared. Some people sought refuge in merriment or luxury and self-indulgence. Others became preoccupied with grisly subjects. Inspired by Black Death, Danse Macabre (Dance of Death) is an allegory consisting of the personified death leading a row of dancing figures from all walks of life to the grave. They were typically with an emperor, king, pope, monk, youngster, and beautiful girl, all in skeleton-state. They were produced to remind people of how fragile their lives were and how vain the glories of earthly life were on the universality of death. Many frantically performed the Dance of Death in cemeteries, while others secretly celebrated the Black Mass, mimicking religion in a mad desire to appease the devil. The Black Death led to cynicism toward religious officials who could not keep their frequent pr omises of curing plague victims and banishing the disease. No one, the Church included, was able to cure or even explain the plague. In fact, most thought it spread somehow through air. This increased doubting of the clergy. Pope Clement VI reigned during the plague years in Europe during a time when the papacy was based in Avignon, France. This period in papal history, known as the Babylonian Captivity to its detractors, was a concurrent cause of the peoples lack of faith in the Catholic Church. The Avignon popes were seen as having subordinated themselves to the French monarchy and their ineffectiveness regarding the Black Death only compounded the common mans disillusionment. Extreme alienation with the church culminated in support for different religious groups such as the Order of Flagellants, which grew tremendously during the opening years of the Black Death angering church and political officials greatly. Flagellants practiced self-flogging to atone for sins. Its members wen t into the streets, two by two, beating each other with chains and whips. Flagellants traveled from town to town and were often looked upon as spreaders of the disease. The Black Death hit the monasteries very hard because of their close quarters and their kindness in helping the sick. There was a severe shortage of clergy after the epidemic cycle. This resulted in a mass influx of new clergy members, most of whom did not share the life-long convictions and experiences of the veterans they replaced. The result was abuses by the clergy in the years afterwards and a further deterioration of the position of the Church in the eyes of the people. The Black Death had an effect on the arts. After 1350 European culture in general turned very morbid. The general mood was one of pessimism, and the arts turned dark with representations of death. Both sculptors and painters began to portray the dead and dying, as well as images of death and the grim reaper. Peoples attitudes towards music and art changed as they began to see the depression surrounding them. The horrific nature of the Black Death was reflected in the realistic depictions of human suffering and carnage as well as the symbolic use of the skeleton. In Giovanni Boccaccios Decameron, a group of young people fleeing the plague takes refuge in a house outside of Florence where they entertain each other with colorful and irreverent stories. While these stories are often seen as a rejection of traditional medieval values, Boccaccio himself was critical of those who abandoned relatives and friends in the face of the plague. Like the artists of the day, Boccaccio continued to h old traditional social and religious values. The primary impact of the Black Death on painting and sculpture was the willingness of the newly rich to invest in religious art for churches and chapels. These contributions were often made in gratitude for being spared the plague, or with the hope of preventing future infection. The science of alchemy was also affected by the plague. As a specialty and method of treatment, it was considered the norm for most scientists and doctors prior and during the Black Death. However, after the plague had taken its toll, the practice of alchemy slowly began to wane. The citizenry began to realize that, in most cases, it did not affect the progress of the epidemic and that some of the potions and cures used by many doctors throughout Christendom and the Islamic world only helped to worsen the condition of the sick. Because the stench of decaying bodies from those who had succumbed to the plague was so noxious, many thought that the plague was spread via the atmosphere and so used pungent scents hoping to keep it away. Scents such as pine and rosemary were burned like incense or processed into oils in which handkerchiefs were dipped and placed over the mouth and nose. Church bells were chimed in a futile bid to ward off the plague. Merchants sold charms and spells to ward off the plague. Rumors that claimed a person had done or worn something particular to survive led to the newest fad to prevent or cure the disease. Liquor, originally made by alchemists, was commonly applied as a remedy for the Black Death, and as a result the popularity and consumption of liquor in Europe rose dramatically after the plague. The Black Death was a historical event of great magnitude, and one with many consequences. The indirect influences on history are significant and give rise too many speculations on what might have happened had there been no Black Death. The impact of plague was greater on England than any other European country. The Black Death struck such a blow to the already weakened feudal system that it lost much of its meaning within two generations and had entirely disappeared within 150 years. On the European continent, the system was more rigid and lingered on for centuries, giving way year by year in one country after another to monarchy and other forms of government. The Black Death greatly accelerated social and economic change during the 14th and 15th centuries. It also led to peasant uprisings in many parts of Europe, such as France (the Jacquerie rebellion) and in Italy (the Ciompi rebellion, which swept the city of Florence). One of the groups that suffered the most was the Christian church. It lost prestige, spiritual authority, and leadership over the people. The church promised cures, treatment, and an explanation for the plague. They said it was Gods will, but the reason for this awful punishment was unknown. People wanted answers, but the priests and bishops did not have any. Many of the clergy abandoned their Christian duties and fled. People prayed to God and begged for forgiveness. After the plague ended, angry and frustrated villagers started to revolt against the church. The survivors were also enraged at doctors, who said they could cure patients but did not. Soon after the last eruption of the Black Death, the views on children also changed. Although carrying on the family name was still considered important, the birth rate dropped. Children were considered not worth the trouble to rise since they would probably die anyway. It took four hundred years before Europes population equaled the pre-Black Death figures. The demand for agricultural workers ga ve survivors a new bargaining power. Workers formerly bound to the land could now travel and command higher wages for their services. In addition, people left rural areas and migrated to cities for higher wages. The economic structure of land-based wealth shifted. Portable wealth in the form of money, skills, and services emerged. Small towns and cities grew while large estates and manors began to collapse. The very social, economic, and political structure of Europe was forever altered. One tiny insect, a flea, toppled feudalism and changed the course of history in Europe.

Antisense Technology and Its Applications

Antisense Technology and Its Applications ANTISENSE TECHNOLOGY AND ITS APPLICATION INTRODUCTION: The tool that is used for the inhibition of gene expression is called Antisense technology. The antisense nucleic acid sequence base pairs with its complementary sense RNA strands and thus prevents it from being translated into a protein. The complementary nucleic acid sequence can be either a synthetic oligonucleotide, like oligodeoxyribonucleotides (ODN) having less than 30 mucleotides or longer antisense RNA (aRNA) sequences (Sczakiel, 1997). Example of sense and antisense RNA is: 5’ A C G U 3’ mRNA, and 3’ U G C A 5’ Antisense RNA. Dr. Hal Weintraub first developed this technology at Basic Science Division. Firstly, they showed that aRNA inhibits the gene expression in mouse cells by Berg, 2002. Dr. Meng-Chao Yao in 1996 showed that aRNA that was incorporated into non-conserved regions of ribosomal RNA (rRNA) disrupts translation and this was done by altering interaction of the mRNA, and the rRNA, mRNA chimera. Sequence transcription of antisense DNA strand into the sense mRNA strand, which is then translated into polypeptide (Kimball, Nov 2002). The inhibition in which the theory works are as follows: When the RNA binds to the complementary mRNA, it forms a double stranded RNA (ds RNA) complex which is similar to double stranded DNA . The dsRNA complex do not allow translation to occur. This translation process was not known. Several theories include: dsRNA prevents ribosome from binding to the sense RNA and translating. dsRNA cannot be translated from nucleus to cytosol, where the translation occurs. dsRNA is susceptible to endoribonucleases that does not affect single stranded RNA, but degrade the dsRNA. ANTISENSE OLIGONUCLEOTIDES: Oligonucleotide-based antisense techniques represents the most successful approach to genetic message element. Zamecnik and Stephenson first demonstrated the antisense effect of synthetic nucleotide. Zamecnik and Stephenson identified a repeated sequence of 21 nucleotides (nt) that was crucial to viral integration with the help of nucleotide sequences from the 5’ and 3’ ends of the 35S RNA of Rous sarcoma virus (RSV). They synthesized a 13-mer oligonucleotide, d(AATGGTAAAATGG), complement to the portion of this viral sequence. Viral production got inhibited when synthetic oligonucleotide was introduced into cultured fibroblast cells.Thus, they concluded that oligonucleotide was inhibiting viral integration by hybridizing to the crucial sequences and blocking them. They introduced the term ‘hybridon’ to describe such oligonucleotides. At the same time, Tennant et al and Miller et al reported similar effects for synthetic oligonucleotides in other systems. These results focused on the ability of synthetic oligonucleotides to interfere with gene processes. Synthetic oligonucleotides are foreign to the cells into which they are introduced and thus becomes prey for endogenous nucleases. Synthetic oligonucleotides were protected from endogenous nuclease when they attained the persistence level in cell. There are three possible sites on a nucleotide where protective modifications could be introduced. The three possible sites are Base, Ribose (2’ OH group) and the Phosphate backbone. In RNA nucleotides the 2’ hydroxyl group, missing in DNA nucleotides, can be modified. The alteration was thus introduced in the protective modifications of nucleotides that protects against the nuclease degradation which does not at the same time eliminates the desired effect of the oligonucleotide sequence by blocking the complementary hybridization or harming of the cells. In the late 1960s, Eckstein and colleagues successfully introduced the first-generation antisense-motivated nucleotide modification. They replaced one of the non-bridging oxygen atoms in the phosphate backbone with a sulfur atom. This modification was called as phosphhorothioate that achieved the goal of nuclease resistance measured by an increased half-life for a phosphorothioated oligonucleotide upto ten hours in human serum as compared to that of one hour of an unmodified oligonucleotide having the same sequence. Moreover, Matsukura and colleagues demonstrated that phosphorothioated oligonucleotides were effective hybridons against the HIV replication in the cultured cells. On the other hand, phophorothioated oligonucleotides displayed slightly reduced hybridization kinetics and a tendency towards unspecific binding with certain proteins which resulted in cytotoxicity at high concentrations. Thus, the dose-response was added to the mix of issues for antisense agents and hence the useful modifications continued. The so called second-generation class of modifications directly addressed the non-specific and cytotoxic issues which was raised by the phosporothioates by the introduction of RNA oligonucleotides with alkyl modifications at the 2’ position of the ribose sugar. The two most important of these modifications are 2’-O-methyl and 2’-O-methoxy-ethyl RNAs. Antisense nucleotides contains these modifications and displayed the nuclease resistance in concert with lower toxicity and major drawback of 2’-O-alkyl modifications is that the antisense agents containing them are unavailable to the most powerful antisense mechanism called RNase H cleavage. Steric block mechanism are affected from these agents. Thus, the 2’-O-methyl oligonucleotides have been used to increase the desired expression of alternate splices in certain proteins by suppressing the undesired splice variant. Since RNase H cleavage is the most desirable mechanism for antisense effect. Nuclear resistance rarely have 2’-O-alkyl modifications which is a hybrid oligonucleotide, constructs incorporating both the characteristics has been appeared in the form of the â€Å"gapmer† antisense oligonucleotide, containing central deoxynucleotide blocks sufficient to induce RNase H cleavage which was flanked by the blocks of 2’-O-methyl modified ribonucleotides, thus protecting the internal blocks from nuclease degradation and these irrelevant cleavage appears because of binding short stretched nucleotide in most of the genomes. For example, a 15-mer can be viewed as a series of eight overlapping 8-mers. mRNA has less potential random targets, while in RNase H cleavage it is still high. This theoretical potential became real in the case of 20-mer phophorothioate oligonucleotide targeted to the 3’-untranslated region (UTR) of the protein kinase C alpha gene (PKCÃŽ ±). While unmodified oligo-deoxynucleotides forms desired DNA:DNA and DNA:RNA duplexes. A variety of nucleic acid analogs have been developed by that increased the thermal stabilities when hybridized with the complementary DNAs or RNAs as compared to unmodified DNA:DNA and DNA:RNA duplexes. These are third generation antisense oligonucleotide modifications and the analogs are: peptide nucleic acids, 2’-fluro N3-P5’-phosphoramadites, 1’, 5’-anhydrohexitol nucleic acids, and locked nucleic acids. The newest and most promising third generation modification is the locked nucleic acid (LNA), introduced by Koshkin et al, Obika et al and Singh et al. LNA, is thus composed of locked nucleotides into a single conformation through a 2’-0’, 4’-C methylene linkage in 1,2:5,6-di-O-isopropylene-ÃŽ ±-allofuranose. LNAs increased the thermodynamic stability and enhanced nucleic acid recognition. Ribozymes: Ribozymes are RNA enzymes were first described by Cech in Tetrahymena thermophilia. Antisense agents immediatley seized the RNA processing capabilities of these enzymes. Thus, the hammerhead ribozyme was characterized. This enzyme was first isolated from viroid RNA by Ulhenbeck and Haseloff and Gerlach. RNA Interference (RNAi): RNA interference (RNAi) was first described by Fire and colleagues in Caenorhabditis elegans. Long-double stranded RNAs were introduced into C. elegans. RNAi generated enormous interest by both those who view it as a potentially powerful antisense tool and recognize it like ancient eukaryotic cellular defense mechanism. ANTISENSE MECHANISM: The overall goal in introducing an antisense agent into the cells either in vitro or in vivo is to suppress or completely block the production of the gene product. The normal transcription and translation is affected due to transition between DNA and amino acid sequence. DNA strand is transcribed into pre-mRNA at step one. In step two, through the action of 3 separate processes like 5’ capping, intron excision and polyadnelyation, pre-mRNA is converted into mature mRNA. In step three, transportation of mRNA is carried out in ribosomes into the appropriate poly-peptide. The first target is transcription step to achieve antisense knock-down or knock-out, in which antisense agent is targeted to DNA itself, thus preventing transcription of the primary message. Dagle and Weeks noted that there are three ways in which this strategy can be carried out viz, minor groove binding polyamides, strand displaying PNAs, and major groove binding , triplex forming oligonucleotides. According to White at al, pyrrole-imidazole are minor groove binding polymers that achieve sequence-specific action through side-by-side pairing of pyrrole and imidazole amino acids. Less than 7bp appears in the target sequence of short stretched DNA. While PNA agents are longer and their mode of operation binds to complementary strand of DNA helix, displacing the complement. This process is thus aided by the fact that PNA:DNA duplexes are more stable than the DNA:DNA duplexes so that former is thermodynamically favored over the latter duplex. Triplex forming oligonucleotides have longer sequences and these agents create stable triplex DNA instead of binding to one of the DNA helix, while displacing the other helix of DNA. Both involves the interaction of TFO having purine bases in a polypurine:polyrimidine stretch of duplex DNA. Watson-Crick bonded is the target dsDNA sequence and triplex forming oligonucleotides binds to duplex through Hoogsteen hydrogen binding: T-A:T and C-G:C triplets. This strategy necessitates that only the purine-pyrimidine dsDNA can be targeted and the cytosine in TFO must be protonated. Thus the cytosine protonation is due to the requirement for the acidic conditions. Sorensen et al reported that the LNA containing TFOs stabilizes the triplex formation at physiologic pH. A 15-mer having seven LNAs raised the temperature for the triplex to duplex transformation from 33 °C to ~66 °C at pH 6.8. The next level of antisense attack focuses on the processing of the pre-mRNA and the intron excision mechanism. In this process, the oligonucleotide-based agent is used. The sequence-specific binding of the oligonucleotide to the pre-mRNA is required to prevent intron-excision. The antisense agent is then targeted to the mature rRNA and interferes with the transcription apparatus in either due to presence of the oligonucleotide which prevents formation of the ribosomal complex. In ribosomal complex, short RNA oligonucleotides are not stable due to presence of helicase enzymes, while longer RNA oligonucleotides activates RNAi pathway. Finally the most used mechanism is that of the RNase H degradation of mRNA. RNase H is an endogenous enzyme which cleaves the RNA moiety of an RNA:DNA duplex. In both cytoplasm and nucleus, RNase H is found. During DNA replication it removes the primers of RNA from Okazaki fragments. The most powerful weapon assessing functions of gene is called RNase H activation antisense. Kurreck thus listed 15 antisense oligonucleotides in total that are used in clinical trials against the diseases like cancer and asthama. APPLICATIONS OF ANTISENSE TECHNOLOGY: In Medicine: James Watson and Francis Crick proposed deoxyribonucleic acid, which consists of two deoxyribonucleotide molecules each having 5’and 3’end that defines a polarity for the DNA strand. After binding of these strands in antiparallel orientation 3’ of one being juxtaposed to 5’end of the other, they compose a complete DNA molecule. The two stands are bound together by pairing four complementary bases in each strand such that adenine present on one strand binds to second thymine, while cytosine binds to guanine in the second. Each strand contains all the genetic information called as mirror image. This structure permits transmission of genetic information by allowing a complementary strand produce for a single strand. One strand can therefore produce an entire DNA molecule, occurring during the cell division. Each triplet set of nucleotides on a strand of DNA encodes an amino acid. In this process, one or another portion of one strand (a gene) is copied by ribonucleic acid polymerase II producing a compelementary molecule of ribonucleic acid, or RNA. This messenger RNA (mRNA) therefore, contains the same information which is contained in the gene that has been transcribed. Mature RNA molecule is left when the introns are excised. RNA molecule is thus exported to the cell, directing protein synthesis at ribosome. This takes place after intron excision and additional process. Formulation of Antisense Technology: DNA/RNA physiology is applied in various methods. Antisense technology is the most important application used. Here, oligonucleotide is introduced into cell which binds to its target mRNA through complementary based-pairing. This binding forms RNA dimer in cytoplasm and halts the protein synthesis. . Application of Antisense Technology invitro: Antisense technology is used successfully in two general areas. The first one is fundamental research where antisense oligonucleotides introduced helps to determine the role of a specific gene. Cell growth and other changes occurred due to the production of angiotensin II. Cellular renin angiotensin system played an important role in variety of cardiovascular disorders like artherosclerosis and vascular hypertrophy. Oligonucleotides were developed to inhibit the synthesis of angiotensin as it was difficult to demonstrate cellular system to be operative. It is a substrate form which the cells make angiotensin II. Cells make their own angiotensin II having growth promoting effects with the help of this technology. Therapeutic Application of Antisense Technology: Viral infections can occur when the antisense oligonucleotides are complementary to viral RNAs. Similarly, antisense oligonucleotides directed towards the oncogene product plays an important role to reduce growth of cancer cells. The most widely used application of this technology is in gene therapy. In this case, a variety of vectors are used to introduce antisense encoding genes into larger number of cells in a patient or animal to produce long term inhibition of protein. For example, vectors having angiotensin II receptor sequences when introduced in animal models can cause long term normotension in hypersensitive animals. REFERENCES: Damha, Masad. 2002 Oct 17. Making sense of Antisense. http://www.erin.utoronto.ca/mbiotech/menu/damha.htm> Accessed 2003 Feb 11. Tennant RW, Farelly JG, et al. (1973) Effects of polyadenylic acids on functions on murine RNA tumor viruses. Journal of Virology, 12: 1216-1225. Kurreck J. (2003) Antisense technologies: Improvement through novel chemical modifications. European Journal of Biochemistry, 270: 1628-1644. Miller PS, Braiterman LT, and Ts’ o POP. (1977). Effects of a trinucleotide ethyl phosphotriester, Gmp(Et)Gmp(Et)U, on mammalian cells in culture. Biochemistry, 16: 1988-1996. 1

Who Am I? Essay example -- Writing Education Essays

Who Am I? Today as I look back at the first paper that I wrote for this class, I see that it is not the type of paper that I usually write. It is not full of big, sophisticated words. Rather it is a paper that does what it is supposed to, explain in simple english my thoughts on the subject. Those thoughts are that today most college kids are whiners and students go to college because it is the norm. I also gave a couple of abstracts to these. I never really took a stand as to which of those pertained to me. But I think that they all do in a sense. In a way I am irresponsible. I leave stuff to the last minute, I cram, and I get a attitude and just say screw it. As for the metaphor part of the first paper, I do feel that I am a parent and the university is my child. This interpretation is sort of like a cartogram. A cartogram is a map that is distorted to a relationship between two distinctive regions. The regions in this case is the university and myself. This is distorted because the universi ty is much larger than me, and it takes care of me. The second metaphor that I pondered is a little more down to Earth. The university is our god, and if we do not give, we shalt not receive. All of these lead into who I am. In essence I am a hippocrate. I condemn the students who procrastinate, while I am one of the worst at procrastinating. Take this paper for example. I am sitting at my roommates computer, it's eight o'clock Tuesday night, and I'm drinking a whiskey-coke. I already mentioned the child/parent thing. The god part of it is the same, though. I feel I am a god. I can so all of this and still get the grades. At least that the way it seems to be. In actuality I tried it, and it didn't work. The person who wrote the paper is no... ...y writing, I do not see myself. I see someone that's pleasing the audience with what he writes, but not pleasing himself. I am not happy writing stuff that is drab and has to sense of commitment. But that is what has always been a requirement. I like writing this kind of paper better. A paper that I can write with some sort of enthusiasm, eventhough I am better at writing the other kind. Writing this way just makes me feel better. I don't know, call me kooky. In the first paper I wrote with a very prominent mask. But as the papers progressed, I think that I might have been starting to shed that mask a little. Maybe it was the different style of writing. Maybe it was just me. Maybe it was due to the E-mail discussion, where got to people with out even talking to them directly. I don't know. The experience has been really productive. I just hope I can keep it up.

Performance Assessment Essay -- essays papers

Performance Assessment Not since the development of the objective paper and pencil test early in the century has an assessment method hit the American educational scene with such force as has performance assessment methodology in the 1990s. Performance assessment relies on teacher observation and professional judgment to draw inferences about student achievement. The reasons for the intense interest in an assessment methodology can be summarized as follows: During the 1980s important new curriculum research and development efforts at school district, state, national and university levels began to provide new insights into the complexity of some of our most valued achievement targets. We came to understand the multidimensionality of what it means to be a proficient reader, writer, and math or science problem solver, for example. With these and other enhanced visions of the complex nature of the meaning of academic success came a sense of the insufficiency of the traditional multiple choice test. Educat ors began to embrace the reality that some targets, like complex reasoning, skill demonstration and product development, "require"--don't merely permit--the use of subjective, judgmental means of assessment. One simply cannot assess the ability to write well, communicate effectively in a second language, work cooperatively on a team, and complete science laboratory work in a quality manner using the traditional selected response modes of assessment. As a result, we have witnessed a virtual stampede of teachers, administrators and educational policy makers to embrace performance assessment. In short, educators have become as obsessed with performance assessment in the 1990s as we were with the multiple choice tests for 60 years. Warnings from the assessment community (Dunbar, Kortez, and Hoover, 1991) about the potential dangers of invalidity and unreliability of carelessly developed subjective assessments not only have often gone unheeded, but by and large they have gone unheard. Now that we are a decade into the performance assessment movement, however, some of those quality control lessons have begun to take hold. Assessment specialists have begun to articulate in terms that practitioners can understand the rules of evidence for the development and use of high quality performance assessments (e.g. Messick, 1994). As a result, we are well i... ... student performance in specific academic disciplines. If and when such opportunities arise, thorough training is essential for all who are to serve in this capacity. If the teachers issuing this invitation have developed or gleaned from their professional literature refined visions of the meaning of academic success, have transformed them into quality criteria and provide quality training for all who are to observe and evaluate student performance, this can be a very rewarding professional experience. If these standards are not met, it is wise to urge (and perhaps help with) a redevelopment of the assessment. The third and final contact for counselors is as an evaluator of students within the context of the guidance function, observing and judging academic or affective student characteristics. In this case, the counselor will be both the developer and user of the assessment and must know how to adhere to the above mentioned standards of assessment quality. For all of these reasons, it is advisable for school guidance and counseling personnel to understand when this methodology is likely to be useful and when it is not and how to design and develop sound performance assessments. Performance Assessment Essay -- essays papers Performance Assessment Not since the development of the objective paper and pencil test early in the century has an assessment method hit the American educational scene with such force as has performance assessment methodology in the 1990s. Performance assessment relies on teacher observation and professional judgment to draw inferences about student achievement. The reasons for the intense interest in an assessment methodology can be summarized as follows: During the 1980s important new curriculum research and development efforts at school district, state, national and university levels began to provide new insights into the complexity of some of our most valued achievement targets. We came to understand the multidimensionality of what it means to be a proficient reader, writer, and math or science problem solver, for example. With these and other enhanced visions of the complex nature of the meaning of academic success came a sense of the insufficiency of the traditional multiple choice test. Educat ors began to embrace the reality that some targets, like complex reasoning, skill demonstration and product development, "require"--don't merely permit--the use of subjective, judgmental means of assessment. One simply cannot assess the ability to write well, communicate effectively in a second language, work cooperatively on a team, and complete science laboratory work in a quality manner using the traditional selected response modes of assessment. As a result, we have witnessed a virtual stampede of teachers, administrators and educational policy makers to embrace performance assessment. In short, educators have become as obsessed with performance assessment in the 1990s as we were with the multiple choice tests for 60 years. Warnings from the assessment community (Dunbar, Kortez, and Hoover, 1991) about the potential dangers of invalidity and unreliability of carelessly developed subjective assessments not only have often gone unheeded, but by and large they have gone unheard. Now that we are a decade into the performance assessment movement, however, some of those quality control lessons have begun to take hold. Assessment specialists have begun to articulate in terms that practitioners can understand the rules of evidence for the development and use of high quality performance assessments (e.g. Messick, 1994). As a result, we are well i... ... student performance in specific academic disciplines. If and when such opportunities arise, thorough training is essential for all who are to serve in this capacity. If the teachers issuing this invitation have developed or gleaned from their professional literature refined visions of the meaning of academic success, have transformed them into quality criteria and provide quality training for all who are to observe and evaluate student performance, this can be a very rewarding professional experience. If these standards are not met, it is wise to urge (and perhaps help with) a redevelopment of the assessment. The third and final contact for counselors is as an evaluator of students within the context of the guidance function, observing and judging academic or affective student characteristics. In this case, the counselor will be both the developer and user of the assessment and must know how to adhere to the above mentioned standards of assessment quality. For all of these reasons, it is advisable for school guidance and counseling personnel to understand when this methodology is likely to be useful and when it is not and how to design and develop sound performance assessments.

Pretty Little Liars Book Review

ENG2D1-03 22 April 2013 Pretty Little Liars The book I have chosen to do a review on will be on the New York Times best-seller novel written by Sara Shepard Pretty Little Liars. Pretty Little Liars is a drama/mystery book that was released in 2006 and has since then had rave reviews and been produced into a television series that is ongoing. The theme of the book is all about your secrets and how they can come back to haunt you and how they play an important role in your life.I choose to do this book because after watching the spin-off into a television series I was intrigued and curious on how it would differ from the television show. My first impression was â€Å"Wow! This is way better than the TV show† because of the little details added and the mesmerizing words I was baffled and fascinated on how the book would end. In the book Pretty Little Liars there are four main protagonists which are Aria Montgomery, Hanna Marin, Emily Fields, and Spencer Hastings and an antagonist â€Å"A†. This book all revolves around their struggles, love life, and primarily the secrets they have.To begin, I will talk about Aria Montgomery a bohemian hipster that likes vintage clothing and has an artsy personality. Montgomery is a resilient teenage girl because she has gone through the affair of her father and her family issues at home. The author states, â€Å"Before he could answer, Aria shot out of the car, blood rushing in her eyes. How was she supposed to be Icelandic Aria, who left the past behind, if one of her worst memories of Rosewood kept bubbling to the surface. † (Shepard, 100) Indeed, this quote reflects Aria’s hardship but also fitting in did not come easy for her.For example, Aria was constantly looked at as an unordinary person for her pink highlights and stuffed pig named Pigtunia when she was on adolescent. The author states, â€Å"Not only was she talking to a cute, smart guy about Europe but, this might be the only guy in Rosewoo d who didn’t know her as Aria – the weird friend of the pretty girl who vanished. † (Shepard, 39) Obviously, this quote reflects Aria’s life before she went to Finland and how she’s been forgotten. The second protagonist I will be talking about is Hanna Marin a confident girl that trives to be popular and never go back to how she used to be. Hannah is very insecure about her appearance and struggles with both bulimia and anorexia. For instance, whenever Hanna eats out of impulse she soon regrets it and makes herself feel as if she’s going to morph into her seventh-grade overweight self again. The author states, â€Å"Hanna was amazed how, even though it had been years since she’d done this, everything felt the exact same. Her stomach ached, her pants felt tight, and all she wanted was to be rid of what was inside her. (Shepard, 122) This quote proves Hanna’s struggle with her appearance is real but it did not come from herself it came from Alison’s constant teasing and always wanting to make her proud. For example, Hanna often wishes Alison could have seen how popular and how she’s transformed to today just for self-satisfaction. The author proclaims, â€Å"But the biggest thing Ali missed? Hanna’s makeover, of course – and it was such a bummer she had. † (Shepard, 46) This evidently confirms Hanna’s ambition to make Alison proud as she tries to appear how Alison used to look like.The next protagonist I will be talking about is Spencer Hastings the ambitious, extremely intelligent girl that has a rivalry with her perfect older sister. Spencer is an extremely competitive girl that is willing to do whatever it takes to win. For example, sometimes she will flirt with her sister’s boyfriend and even kiss them just to get back at her sister. The author states, â€Å"She’d merely wanted to flirt – Ian was wasting all his hotness on her plain vanill a, goody-two-shoes sister-so she gave Ian a peck goodbye on the cheek.But when he pressed her up against his passenger door, she didn’t try to run away. † (Shepard, 57) Another thing is Spencer is often quick to jump to conclusion For example, when Andrew Campbell asked her about how she’s doing since Melissa’s home she automatically thought he was the person who wrote her the email â€Å"A†. The author proclaims, â€Å"What if†¦ what if Andrew was the one skulking around spying on her? What if Andrew wrote the creepy â€Å"covet† email? Andrew was so competitive it seemed possible. † (Shepard, 144) Thus proving Spencer usually assumes something without looking at the big picture.The last protagonist is Emily Fields a dedicated swimmer that has a kind personality. The author states, â€Å"She was nearly a straight-A, four-time state champion butterflyer and a hyper-obedient daughter. † (Shepard, 100) Emily also tends to wan t things she cannot have (i. e. Maya) her being bisexual was forbidden so they kept quiet and did not say anything. The disappearance and later announced death of Alison impacted her greatly as she found it hard to love again and share her feelings this is Emily’s character.The antagonist of the novel is â€Å"A† an unknown identity that knows all the girls secrets and manipulates them to do whatever they want. With â€Å"A† not only does this person know secrets about the past that only Alison knew but also the present as well. I believe â€Å"A† is very smart because they never leave a trace or clue behind making them very sneaky. For example, when Hanna had got arrested for stealing and also the time she crashed Sean’s car the only person else who knew and was with her was Mona so how did â€Å"A† get a hold of the information.The author states, â€Å"She checked the note’s address again, but it was just a mess of letters and numb ers. † (Shepard, 96) This proves that â€Å"A† is highly intelligent because she makes sure when sending the ‘liars’ a text her name/addressed cannot be traced. These are the characters in the novel Pretty Little Liars. This book takes place in numerous settings in Rosewood Pennsylvania. There is Maya’s former Alison DiLaurentis’ house, the Kahn’s annual party and the AP English class that they are all in. With Alison’s old house Emily reminisces a lot and feels her presence in a way.The author states, â€Å"The first thing she saw when she pulled up to Alison’s old Victorian Home at the top of the leafy street was a huge pile of trash on the curb and a big sign marked, FREE! † This gives us an understanding on how Alison’s old home looked like. *** The main setting is AP English class with Mr. Fitz (Ezra). In here we get a sense of forbidden love between the both of them. For example, even though they cannot be together Aria still tries. The author states, â€Å"But this isn’t meant to be, you know? ‘Cause, well, you’re my student. I could get in a lot of trouble.You don’t want me to get in trouble, do you? † (Shepard, 103) I think it was an excellent and professional way of Ezra showing Aria they cannot be together. Although there is tender awkwardness in the atmosphere between her and the class because of â€Å"the fly† incident I think the student –teacher barrier should not go any further. These are the settings in the book and how they affect the characters. Pretty Little Liars is a book that talks about forbidden love but primarily secrecy. It seems like everyone in Rosewood is in love with someone they cannot have. There is Aria and her English teacher Mr.Fitz, Spencer and her sister’s boyfriend Wren, Emily and her bisexual friend Maya, and lastly Hanna and the guy of her dreams Sean who always rejects her. In the beginning of the book it starts off with Alison’s disappearance during a sleepover the summer before eighth grade and jumps three years later to a time where the girls have grown apart and live their separate lives. Alison was friends with the exclusive group of girls she was vindictive, manipulative and what you would call the â€Å"queen-bee† of the pack. Before the disappearance, of their beloved friend the ‘liars’ lives were oh so different.Aria was known as the â€Å"odd-ball† of Rosewood, Emily was still a passionate swimmer but had at the time secret feelings for Alison, Hanna was an overweight nerd that strived to be like Alison, and Spencer was still the over-achieve but was the only brave enough to stand up to Alison. The ‘liars’ are a junior in high school now and the disappearance of their old friend has been forgotten about. Suddenly all of the ‘liars’ begin receiving text messages from â€Å"A† an anonymous perso n that knows all of their secrets and stuff from the past.

The Great Gatsby has been described as a definitive record of the glamorous side of the Jazz Age

The Great Gatsby is full of lavish spending, huge parties and all round hedonistic enjoyment, showing a ‘definitive record of the glamorous side’ of the 1920s on every level. America in the 1920s had the highest living standard in the world, the United States owned around 40% of the entire world’s wealth, with this money the established rich spent their time living a glamorous lifestyle. In the 1920s the class of the established rich certainly knew how to be glamorous, as Fitzgerald shows through Daisy and Tom Buchanan. The Buchanan’s house was ‘more elaborate’ then Nick expected, it was a ‘Georgian Colonial mansion,’ and they also had luxury items such as a ‘motor boat’ and ‘horses.’ Tom obviously took pride in his house and processions, saying that he has ‘got a nice place.’ The money was also spent immorally; they always seem to have a plentiful amount of alcohol, like ‘the cocktails’ which Tom drank like ‘it was a drop on the bottom of a glass’ showing he must drink a lot. This alcohol was bought illegally as prohibition was in place from 1920 to 1933 which banned the manufacture, sale and transportation of liquor in the USA. RACISM Not only did the established rich have luxury items, they also did not work for their money, giving them plenty of free time to spend as they please, Jordan Baker had enough time to take up golfing, and ‘play in tournaments.’ Yet with all this money and free time the Buchanan’s lives are unfulfilled as they have spiritual goals, Daisy is unhappy in life and questions her purpose in life by saying ‘What shall we do this afternoon? And the day after? And the next thirty years?’ this showing the darker side to the 1920s. Fitzgerald shows glamour through Gatsby’s extravagant parties, Gatsby is new money as he worked for his money. From Gatsby’s ridiculous quantities of oranges to ‘the orchestra’ which played at his parties, Gatsby made sure that his parties were glamorous. At first Gatsby’s parties seem magical, as Gatsby’s ‘blue gardens were alive with the whispering and the champagne and the stars.’ The ‘floating rounds of cocktails permeated the garden’ and the ‘air was alive with chatter and laughter,’ everybody seemed to be having a fantastic time. Fitzgerald and his wife Zelda would have known first-hand how glamorous these jazz age parties were as they often attended them and they lived a glamorous life style. Yet underneath the glamour of Gatsby’s parties we see the bleaker side of the 1920s. Fitzgerald shows the work put in to the parties, to make the orange juice a butler had to press ‘a little button†¦ two hundred times.’ After the parties ‘eight servants†¦ toiled all day with mops and scrubbing-brushes†¦ repairing the ravages of the night before,’ as the party guests left so much destruction in their way. Gatsby’s parties may be glamorous but he paid a great deal to make them this way. It is alleged that Gatsby made his money immorally, by bootlegging, Tom suggests this when he said ‘I picked him for a bootlegger the first time I saw him.’ It was easy to make money illegally in the 1920’s, due to prohibition many found it easy to sell alcohol over the counter or to speakeasies, which were secret bars in the 1920s, these people were often called bootleggers. This was an illegal way of getting the money; showing unglamorous, illegal acts were done to make these glamorous parties. Therefore alcohol in Gatsby’s parties was plentiful, he even had his own bar, but this alcohol led to carelessness as owl eyes was ‘drunk for about a week’ and alcohol also lead to recklessness in the form of car crashes, and violent actions with women ‘kicking off into the night, dragged away by men said to be their husbands.’ Gatsby paid a great amount of money but did the guests really care about their host? Nick was ‘one of the few guests, who had actually been invited,’ and of all of the guests who were at Gatsby’s parties only one came to his funeral, this shows the caring attitude and shallowness of people in the 1920s. Despite the unprecedented economic growth and excessive glamorous spending during the 1920s, the gap between rich and poor became increasingly prevalent. As most of the characters are very wealthy the rich and glamorous atmosphere defines the novel’s tone, the focus on the upper class lifestyle gives the novel a mood of extravagance. However, this society is contrasted with the poverty of those living near the Valley of Ashes; which is based on T.S Elliott’s poem ‘The Wasteland’. Like Elliott’s wasteland, the Valley of Ashes is a hideous image of a spiritually dead world, a symbol of the collapse of moral values after the chaos of the war. In the Great Gatsby we see how the Wilson’s live, which is a stark contrast from the Buchannan’s glamorous lifestyle. Nick could not believe that the Wilson’s lived in such a place, he thought the ‘garage must be a blind, and that sumptuous and romantic apartments were concealed overhead. ’ Their lifestyle is so unglamorous; it gives the darker side of the Jazz age. Myrtle Wilson tried hard to climb the classes by having an affair with Tom Buchannan, but even the apartment he provides for her is small and Tom treats her badly, he even breaks her nose, in his eyes she will always be lower than Daisy. George also tries very hard to make his money honestly, when Tom comes in he is so eager to have some business, George is a failure of the American Dream, he will never achieve the glamorous lifestyle he wants to provide.

Guitar theory

However, some exercises are considered to be good for warming up. Warm up exercise 1 This is a nice warm-up exercise that takes you through a great set of stretches. As with any warm-up exercise, take it slow and work up to playing it in time. This exercise is inspired by recommendations by Eric Vandenberg on how to warm-up for them slow!! I play the first 8 bars as chords. I repeat the 8 first bars one fret down, and continue own until I can't stretch it no more.Hence, the tab is more like an outline. My rather small hands are limiting my stretching abilities, and that's why I focus on these exercises also. Bar 9 etc I play note by note. It is still a good stretching exercise, but I can't finger them as chords. Warm up exercise 2 This is a nice warm-up exercise that takes you through 4 notes per string chromatics to 2 notes per string in different fret skipping patterns and finally arpeggiated triplets. This is intended as a warm-up so take it at a relaxing pace with no metronome. L et it get the blood flow moving to your fingers.Try using different finger combinations (1 and 2, 2 and 3,3 and 4, 1 and 3, 2 and 4). The last part will give nice stretches for your fingers. The parts in bar IO- 15 will also give nice stretches if you use adjacent fingers (1 and 2, 2 and 3, 3 and 4). Warm up exercise 3 This exercise was specifically designed as a warm-up exercise. It is intended to stretch your fretting hand and work different finger separations. Take it slow as you should during the warm-up stage of your practice session. Warm up exercise 4 The key purpose of a warm-up exercise is in my opinion to stretch the fingers a little.It's important to do something simple (like walking / light Jogging) before the real work-out starts, and not do something difficult as the warm-up. This easy little stretching exercise should be easy to remember. It starts with a GmaJ7 chord. Then the first finger is lowered down to 1st fret, forming a 67 chord. This gives a good stretch betw een the 1st and 2nd finger. Then the second finger is moved down to the 2nd fret, forming a G7b5 chord. The stretch is now between the 2nd and 3rd finger. The next step is to lower the 3rd finger one fret, forming a Gm7b5 chord.Stretch is now between 3rd and 4th finger. Finally the 4th finger is lowered 1 fret, forming a F#maJ7 chord. Repeat this exercise by starting a fret higher (G#maJ7), or by reversing the progress from the F#maJ7 back to the GmaJ7 chord a few times. You may strum all the chord notes at once or play each note of the chord by alternate picking or by sweeping. Do to my rather small hands I normally start this exercise one octave higher than written in the tab and work my way down rather than working my way up as written in the tab.Warm up exercise 5 Another possible warm up exercise is the so-called spider. Try starting with both an p-stroke and down-stroke (as indicated in the tab). This is really a left hand finger-strength exercise that can be used in the end o f the warm up part of you exercise. Hammer-on all notes in this exercise. Returning by using pull-offs (pull-off with the first finger to an open string) would be a good additional exercise to this one. Warm up exercise 7 Synchronization Exercises In order to play technical difficult stuff, it is very important that both hands are synchronized.The synchronization exercises are intended to improve your synchronization between your left and right hands. The exercises are working on your picking, left hand finger coordination and on your timing. The technique is an important basis to be able to play your musical ideas out on the guitar. You should start your speed improvement by working with these exercises first. Use your metronome. Start slow and get it accurate. Then increase speed. J] Sync 1 A chromatic 16th note exercise. Four notes up four notes down per string. This is a chromatic 16th note exercise.

How Langston Hughes exemplifies the African American Essay

Abstract Prejudice is the key feature in the authors theme. He wants to tell away about how people singles out people based on these people appearances, racial background affiliations and social ranking. Harper Lee has done well to show how the stigmatized people are innocent and oblivious of the prejudices against them. It is common knowledge that it’s way off to kill a mocking bird. The mocking bird in Harpers story is Boo Radley. Boo has not indulged in any harmful activities nor hurt anyone across the social Diaspora. However, Boo is looked down upon due to his social rankings and looks. However, Harper is also determined to show that prejudice is not in any way such a big deal in a sidelined person’s life. He shows courage and human dignity. This is well understood from the actions and feelings of Boo Radley. Prejudice, the self and the Character of Boo To Kill a Mockingbird identifies Arthur Radley as a courageous person. He saw evil in people who committed evil; he sought after positive projections in the society and wished better life for everyone. He is a patriotic and wonderful person. We identify perception about him through the children, they though he was evil based on the rumor ‘he struck his parent with scissors and wiped the bloody scissors with his pants which means he attempted murdering them These rumors scare Jem and Scout and make them eye Boo suspiciously. He is a fearful figure but confident. His character shows self assuredness and focus. Boo is mockingbird, he knows it and is keen on projecting himself as a steadfast and good citizen though looked down as an outcast of Maycomb. Boo has courage and hope. He has been locked away in his house just like Tom who was accused of rape (Lee, 195). Similar prejudices befall Boo, he saves Atticus children and no one looks at if it as anything of importance. However Lee advices against this in pg 90 when he says ‘Shoot all the blue jays you want, if u can hit ‘em, but remember it’s a sin to kill a mockingbird’ (Lee 90).   Killing a mocking bird is also seen when the sheriff is not honest about the death of Bob Ewell. Ewell was stabbed as Boo tried to save Atticus kids. Boo is not convicted for his good deed since the sheriff declares that Ewell fell on his knife and died. Boo indeed sacrificed himself for Jem and Scout. People in Maycomb make wild allegations about him just because he doest seem fit to be one of them. However, we see perseverance, a lot of tolerance and a focus to remain loyal and committed to do good things in Boo. In spite of this prejudice, he serves and helps people. He is kind and a role model. In the book Lee exemplifies these attributes through Boo wrapping a blanket on Scout (Lee p.46).   Boo is also charged with the rape of Mayella Ewell. This is an indication of prejudice, but he doesn’t seem to be in bad terms with his detractors. He is focused on being positive minded. The burning of Maudie’s house is another picturesque that projects the good side of Boo. Boo pities, feels and seeks after doing good rather than watch and laugh as people enjoy ruin Conclusion A mocking bird is more of a social asset rather than a mocking object. We should have a very positive attitude towards people, stop being racist and quit playing apartheid practices. Boo exemplifies exemplary behavior and showcases respect to elders and all other social members without prejudice. We should uphold and force it down to our children and emulate positive attitudes as exemplified by Boo Source Lee Harper (1930)To Kill a Mockingbird   

Epistemological and Methodological Approaches Essay - 2

Epistemological and Methodological Approaches - Essay Example According to the research findings, virtually epistemology in research means the rule of sciences that derive conclusions based on the information and arguments that are derived from the research study. It includes only those information that can be tested by various means. The ontology of research, on the other hand, involves the worldview with which the researcher progresses towards the study. The epistemological approach involves a conceptualizing process which shows how theory involves and how the theory is revised by varying degree. The epistemological approach involves the development of a qualitative approach and the qualitative approach gets validated by the quantitative methods. The quantitative method always has its origin in the qualitative methods because it is not possible that any quantitative derivation can be made without a qualitative basis. The major methodological positions that are involved in a research design are the positivist approach that is the quantitative approach. The positivist approach can also be called a scientific inquiry that emerges from the metaphysical reaction. Positivism is closely related to empiricism that refers to the scientific methods the aim of which is to establish the truth. The idealistic approach is primarily the qualitative approach. According to idealism reality is not separate from the individuals it is created by the individual mind. The positivist approach combined with the idealist methods can produce a good research design. The first study which we will discuss in the paper is based on the fire setter children and the analysis has been given to justify the behavior of those children. Various causes have been put forward as to why the children behave in such an aggressive manner. The study has also taken into account the difference in attitudes between the fire-setter and non-fire setter children. The second study has discussed the role which the disturbed social relations play in making an individual dev iant in nature.